The work will be performed through three main workstreams.

Workstream I: Health-directed requirements, success criteria, governance 

This workstream will establish the best professionally-driven process to specify, design and quality assure the semantic interoperability requirements for particular clinical domains. 
WP1, Patient care exemplar, comprises domain experts from the European Society of Cardiology, who will specify the clinical content needed for high quality and safe integrated care for patients with chronic heart failure, collaborate with the informatics experts in WP4 to develop suitable resources, and define quality criteria for them.
WP2, Public health exemplar, comprises domain experts in public health with focus on the prevention of cardiovascular disease. This WP will follow a parallel approach to WP1.
WP3, Stakeholder validation, unites the experts from WP1 and 2 with a wider range of clinical, professional, patient and ministry experts who will oversee the methodology of WP1 and 2 and ensure that it is generalisable to a wide range of clinical conditions and health care scenarios and focuses on health system priorities. It will define quality and acceptance criteria for semantic interoperability resources, and propose how professional communities can trust and learn to use semantically interoperable solutions. This will become a pragmatic gold standard for trustworthy resources, and a methodology to specify them, that can become the target of the Virtual Organisation.

Workstream II: Harmonised and tailored health informatics resources, tools, methods

This workstream focuses on the technical methodology for designing resources to meet clinical domain requirements, their formal governance and quality assurance, their incorporation into products and eHealth networks.
WP4, Harmonised resources, is a substantial workpackage comprising experts from many SDOs etc. whose task is to combine and adapt their organisations’ products to meet the needs of Workstream I, to publish the resulting resources, and from this to define development guides that can be used for wider semantic interoperability initiatives and inform the future standards development.
WP5, Infostructure and tools, will explore how collections of interoperable resources, e.g. those developed in WP4, can be delivered and maintained through a unified European infostructure. It will also propose recommendations for future tooling and knowledge repositories that can support the consistent and comprehensive Europe wide adoption of such resources.
WP6, Industrial engagement, comprises key companies developing EHR systems and national eHealth infrastructures. This advisory group will oversee the evolving gold standard from Workstream I and the design guidance from Workstream II and ensure that these align with the capability of contemporary and near-term systems and healthcare networks, and are realistic.

Workstream III: Sustainability / Network co-ordination

This workstream is concerned with evolving from an EU funded NoE to a European Virtual Organisation for Semantic Interoperability. WP7, Adoption and sustainability, comprises the widest range of stakeholder experts. For each stakeholder, the requirements, barriers to adoption, success factors, costs and benefits, adoption strategies and incentives will be considered. The workpackage will draw on the experience and expertise from the preceding workpackages 1-6 but especially WP3 and WP 6 which themselves comprise multi-stakeholder expert groups. The outputs of this WP will directly impact on the objectives of the Virtual Organisation.
WP8, European Virtual Organisation, is concerned with establishing the entity itself: its mission, objectives, terms of reference, business model, organisational governance and initial roadmap of activities. This will become the body that asserts what semantic interoperability services need to exist, how they should be established, co-ordinated, overseen and governed. It will advise funding bodies on priorities for research, for education and professional standards, and will advise national eHealth programmes on the maturity of various semantic interoperability approaches and where investments should optimally be made. This WP will draw especially on the European eHealth Governance initiative, and deliberately includes these representatives from several countries.

WP9 Project management, dissemination, promotion

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